Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q7Z3T8
UPID:
ZFY16_HUMAN
Alternative names:
Endofin; Endosome-associated FYVE domain protein
Alternative UPACC:
Q7Z3T8; O15023; Q5H9U2; Q7LAU7; Q86T69; Q8N5L3; Q8NEK3
Background:
Zinc finger FYVE domain-containing protein 16, also known as Endofin and Endosome-associated FYVE domain protein, plays a crucial role in regulating membrane trafficking within the endosomal pathway. Its overexpression leads to endosome aggregation, highlighting its importance in cellular trafficking processes. Additionally, it is essential for targeting TOM1 to endosomes, indicating its pivotal role in cellular sorting mechanisms.
Therapeutic significance:
Understanding the role of Zinc finger FYVE domain-containing protein 16 could open doors to potential therapeutic strategies. Its involvement in membrane trafficking and endosomal pathway regulation presents a unique opportunity for targeting diseases where these processes are disrupted.