Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q7Z3Z0
UPID:
K1C25_HUMAN
Alternative names:
Cytokeratin-25; Keratin-25; Keratin-25A; Type I inner root sheath-specific keratin-K25irs1
Alternative UPACC:
Q7Z3Z0
Background:
Keratin, type I cytoskeletal 25, also known as Cytokeratin-25, Keratin-25, Keratin-25A, and Type I inner root sheath-specific keratin-K25irs1, plays a crucial role in the assembly of keratin protein complexes. It is essential for the formation of keratin intermediate filaments in the inner root sheath, contributing significantly to cytoskeleton organization.
Therapeutic significance:
The protein is linked to Woolly hair autosomal recessive 3, a hair shaft disorder characterized by fine, tightly curled hair with structural anomalies. Understanding the role of Keratin, type I cytoskeletal 25, could open doors to potential therapeutic strategies for this condition.