Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q7Z410
UPID:
TMPS9_HUMAN
Alternative names:
Polyserase-I; Polyserine protease 1
Alternative UPACC:
Q7Z410; Q6ZND6; Q7Z411
Background:
Transmembrane protease serine 9, known as Polyserase-I or Polyserine protease 1, plays a crucial role in peptide hydrolysis. It specifically targets peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC, showcasing its specificity towards serine protease activity. This enzyme's unique substrate preference highlights its potential in biochemical pathways.
Therapeutic significance:
Understanding the role of Transmembrane protease serine 9 could open doors to potential therapeutic strategies. Its precise function in hydrolyzing specific peptides suggests a targeted approach in drug discovery, focusing on diseases where peptide processing is crucial.