Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q7Z4K8
UPID:
TRI46_HUMAN
Alternative names:
Gene Y protein; Tripartite, fibronectin type-III and C-terminal SPRY motif protein
Alternative UPACC:
Q7Z4K8; A0AVI6; B1AVQ4; Q5VT60; Q5VT62; Q6NT17; Q6NT41; Q6ZRL7; Q9H5P2
Background:
Tripartite motif-containing protein 46, also known as Gene Y protein and Tripartite, fibronectin type-III and C-terminal SPRY motif protein, plays a crucial role in the formation of parallel microtubule bundles. These bundles are essential for efficient cargo delivery and trafficking in axons, contributing to proper axon specification, neuronal polarity, and neuronal migration.
Therapeutic significance:
Understanding the role of Tripartite motif-containing protein 46 could open doors to potential therapeutic strategies.