Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q7Z614
UPID:
SNX20_HUMAN
Alternative names:
Selectin ligand-interactor cytoplasmic 1
Alternative UPACC:
Q7Z614; A8K9D5; Q08E98; Q6P4H2; Q8IV59
Background:
Sorting nexin-20, also known as Selectin ligand-interactor cytoplasmic 1, plays a crucial role in cellular vesicle trafficking. It is specifically proposed to function as a sorting protein, targeting SELPLG into endosomes. This process is vital for the regulation of SELPLG, affecting neither its internalization from the cell surface nor SELPLG-mediated cell-cell adhesion.
Therapeutic significance:
Understanding the role of Sorting nexin-20 could open doors to potential therapeutic strategies. Its involvement in cellular vesicle trafficking highlights its importance in cellular communication and transport mechanisms, making it a potential target for therapeutic intervention.