Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q7Z7C8
UPID:
TAF8_HUMAN
Alternative names:
Protein taube nuss; TBP-associated factor 43 kDa; TBP-associated factor 8; Transcription initiation factor TFIID 43 kDa subunit
Alternative UPACC:
Q7Z7C8; Q5T0K1; Q8N4R9; Q96M52
Background:
Transcription initiation factor TFIID subunit 8, also known as TAF8, plays a pivotal role in the initiation of RNA polymerase II-dependent transcription. It is a part of the TFIID basal transcription factor complex, crucial for recognizing and binding promoters, facilitating the assembly of the pre-initiation complex. TAF8, alongside TAF5, contributes to the formation of the TFIID-B module, essential for both basal and activator-dependent transcription.
Therapeutic significance:
Understanding the role of Transcription initiation factor TFIID subunit 8 could open doors to potential therapeutic strategies, especially considering its involvement in a neurodevelopmental disorder characterized by severe motor impairment, absent language, and brain atrophy. This highlights its potential as a target for therapeutic intervention.