Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q7Z7H8
UPID:
RM10_HUMAN
Alternative names:
39S ribosomal protein L10, mitochondrial; 39S ribosomal protein L8, mitochondrial
Alternative UPACC:
Q7Z7H8; A6NGJ4; Q96B80; Q96Q55
Background:
The Large ribosomal subunit protein uL10m, also known as 39S ribosomal protein L10 and L8 in its mitochondrial form, plays a crucial role in protein synthesis. As part of the mitochondrial ribosome, it is involved in translating mitochondrial DNA-encoded proteins, essential for mitochondrial function and energy production.
Therapeutic significance:
Understanding the role of Large ribosomal subunit protein uL10m could open doors to potential therapeutic strategies. Its pivotal function in mitochondrial protein synthesis makes it a key player in cellular energy metabolism, highlighting its potential in addressing diseases linked to mitochondrial dysfunction.