Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q86SE8
UPID:
NPM2_HUMAN
Alternative names:
-
Alternative UPACC:
Q86SE8; B3KSU0; D3DSQ8; Q6NVH6
Background:
Nucleoplasmin-2 plays a pivotal role as a core histones chaperone, crucial for chromatin reprogramming, particularly during fertilization and early embryonic development. Its involvement in sperm DNA decondensation during fertilization underscores its fundamental role in the initiation of life.
Therapeutic significance:
Understanding the role of Nucleoplasmin-2 could open doors to potential therapeutic strategies. Its critical function in early development stages highlights its potential as a target for interventions in fertility and embryonic health.