Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q86SG3
UPID:
DAZ4_HUMAN
Alternative names:
-
Alternative UPACC:
Q86SG3; Q9NR88; Q9NR89
Background:
Deleted in azoospermia protein 4 (DAZ4) plays a pivotal role in male fertility, acting as an RNA-binding protein essential for spermatogenesis. It functions by potentially binding to the 3'-UTR of mRNAs, regulating their translation and ensuring proper sperm development.
Therapeutic significance:
DAZ4's involvement in Spermatogenic failure Y-linked 2, characterized by reduced or absent sperm, highlights its critical role in male infertility. Understanding the role of Deleted in azoospermia protein 4 could open doors to potential therapeutic strategies for treating infertility.