Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q86SU0
UPID:
ILDR1_HUMAN
Alternative names:
Angulin-2
Alternative UPACC:
Q86SU0; Q6ZP61; Q7Z578
Background:
Immunoglobulin-like domain-containing receptor 1, also known as Angulin-2, plays a pivotal role in maintaining epithelial barrier function. It ensures the integrity of tricellular tight junctions crucial for auditory neurosensory health and mediates essential processes in the small intestine. Additionally, it influences influenza virus infection dynamics.
Therapeutic significance:
Given its critical function in preserving hearing by maintaining tricellular tight junctions, Immunoglobulin-like domain-containing receptor 1 is linked to Deafness, autosomal recessive, 42. Understanding its role could lead to novel treatments for sensorineural hearing loss.