Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
Q86U44
UPID:
MTA70_HUMAN
Alternative names:
Methyltransferase-like protein 3; N6-adenosine-methyltransferase 70 kDa subunit
Alternative UPACC:
Q86U44; O14736; Q86V05; Q9HB32
Background:
The METTL3-METTL14 heterodimer, acting as a N6-methyltransferase complex, plays a pivotal role in methylating adenosine residues in RNA. This modification influences various biological processes, including stem cell differentiation, neurogenesis, and the circadian clock. METTL3, as part of this complex, serves as the catalytic core, emphasizing its critical function in these pathways.
Therapeutic significance:
Understanding the role of N6-adenosine-methyltransferase catalytic subunit could open doors to potential therapeutic strategies. Its involvement in fundamental cellular processes and response to DNA damage highlights its potential as a target in regenerative medicine and cancer therapy.