Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q86U90
UPID:
YRDC_HUMAN
Alternative names:
Dopamine receptor-interacting protein 3; Ischemia/reperfusion-inducible protein homolog
Alternative UPACC:
Q86U90; Q4W4X8; Q6NVW3; Q7L4E4; Q7Z2I4; Q9H5F8
Background:
Threonylcarbamoyl-AMP synthase, also known as Dopamine receptor-interacting protein 3 and Ischemia/reperfusion-inducible protein homolog, plays a crucial role in protein synthesis. It is essential for the formation of a threonylcarbamoyl group on adenosine at position 37 in tRNAs that read codons beginning with adenine. This process is vital for the accurate translation of the genetic code into proteins, occurring in both cytoplasmic and mitochondrial tRNAs.
Therapeutic significance:
The protein's involvement in Galloway-Mowat syndrome 10, a severe renal-neurological disease, highlights its clinical importance. Understanding the role of Threonylcarbamoyl-AMP synthase could open doors to potential therapeutic strategies for this condition, which is characterized by early-onset nephrotic syndrome, central nervous system abnormalities, and a fatal outcome.