Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q86UK5
UPID:
LBN_HUMAN
Alternative names:
Ellis-van Creveld syndrome protein 2
Alternative UPACC:
Q86UK5; Q86YT3; Q86YT4; Q8NG49
Background:
Limbin, also known as Ellis-van Creveld syndrome protein 2, is a pivotal component of the EvC complex, enhancing ciliary Hedgehog signaling. This protein is instrumental in bone formation and skeletal development, and may play a role in early embryonic morphogenesis.
Therapeutic significance:
Limbin is directly associated with Ellis-van Creveld syndrome and Acrofacial dysostosis, Weyers type. These genetic disorders, characterized by skeletal dysplasia, dental anomalies, and polydactyly, highlight the protein's critical role in human health. Understanding Limbin's function could lead to novel therapeutic strategies for these conditions.