Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q86UW6
UPID:
N4BP2_HUMAN
Alternative names:
BCL-3-binding protein
Alternative UPACC:
Q86UW6; A0AVR3; Q9NVK2; Q9P2D4
Background:
NEDD4-binding protein 2, also known as BCL-3-binding protein, plays a crucial role in cellular processes with its 5'-polynucleotide kinase and nicking endonuclease activity. These functions suggest its involvement in DNA repair or recombination, essential for maintaining genomic stability.
Therapeutic significance:
Understanding the role of NEDD4-binding protein 2 could open doors to potential therapeutic strategies. Its involvement in DNA repair mechanisms positions it as a key target for developing treatments aimed at enhancing DNA repair pathways, crucial for combating diseases linked to DNA damage.