Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q86V24
UPID:
PAQR2_HUMAN
Alternative names:
Progestin and adipoQ receptor family member 2; Progestin and adipoQ receptor family member II
Alternative UPACC:
Q86V24; Q53YY5; Q9H737
Background:
Adiponectin receptor protein 2, also known as Progestin and adipoQ receptor family member 2, plays a pivotal role in metabolic processes. It serves as a receptor for ADIPOQ, a hormone from adipocytes that is crucial for glucose and lipid metabolism. This receptor is essential for maintaining normal body fat and glucose levels, facilitating fatty acid oxidation and glucose uptake through PPARA activity enhancement.
Therapeutic significance:
Understanding the role of Adiponectin receptor protein 2 could open doors to potential therapeutic strategies.