Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q86VH2
UPID:
KIF27_HUMAN
Alternative names:
-
Alternative UPACC:
Q86VH2; B2RTR8; Q5T6W0; Q86VH0; Q86VH1; Q9UF54
Background:
Kinesin-like protein KIF27, encoded by the gene with the UniProt accession number Q86VH2, is a crucial component in the process of motile ciliogenesis. This protein belongs to the kinesin family, which are motor proteins that move along microtubules in cells and are involved in various forms of cellular transport and dynamics.
Therapeutic significance:
Understanding the role of Kinesin-like protein KIF27 could open doors to potential therapeutic strategies. Its essential function in motile ciliogenesis suggests that it may play a role in diseases related to ciliary dysfunction, although direct associations are yet to be established.