Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q86W92
UPID:
LIPB1_HUMAN
Alternative names:
Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; hSGT2
Alternative UPACC:
Q86W92; O75336; Q86X70; Q9NY03; Q9ULJ0
Background:
Liprin-beta-1, also known as Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1 or hSGT2, plays a crucial role in cellular processes by potentially regulating the disassembly of focal adhesions. This protein's involvement in such a fundamental cellular function underscores its importance in maintaining cellular architecture and signaling.
Therapeutic significance:
Liprin-beta-1's association with Neurodevelopmental disorder with seizures, microcephaly, and brain abnormalities highlights its potential as a target for therapeutic intervention. Understanding the role of Liprin-beta-1 could open doors to potential therapeutic strategies aimed at mitigating the severe impacts of this disorder.