Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q86WV5
UPID:
TEN1L_HUMAN
Alternative names:
Protein telomeric pathways with STN1 homolog; Telomere length regulation protein TEN1 homolog
Alternative UPACC:
Q86WV5; I3L0C7
Background:
The CST complex subunit TEN1, also known as Protein telomeric pathways with STN1 homolog and Telomere length regulation protein TEN1 homolog, plays a crucial role in DNA replication and telomere maintenance. It is a part of the CST complex, which binds single-stranded DNA with high affinity, protecting telomeres from degradation, regulating telomere length, and facilitating recovery from DNA damage.
Therapeutic significance:
Understanding the role of CST complex subunit TEN1 could open doors to potential therapeutic strategies.