Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q86Y34
UPID:
AGRG3_HUMAN
Alternative names:
G-protein coupled receptor 97; G-protein coupled receptor PGR26
Alternative UPACC:
Q86Y34; Q6ZMF4; Q86SL9; Q8IZF1
Background:
Adhesion G protein-coupled receptor G3, also known as G-protein coupled receptor 97 or G-protein coupled receptor PGR26, plays a pivotal role in the regulation of lymphatic endothelial cell migration through the small GTPases RhoA and CDC42. This receptor is also implicated in B-cell development and signals predominantly through G-alpha(q)-proteins.
Therapeutic significance:
Understanding the role of Adhesion G protein-coupled receptor G3 could open doors to potential therapeutic strategies.