Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q86YQ8
UPID:
CPNE8_HUMAN
Alternative names:
Copine VIII
Alternative UPACC:
Q86YQ8; Q2TB41; Q86VY2
Background:
Copine-8, also known as Copine VIII, is identified as a probable calcium-dependent phospholipid-binding protein. This protein is believed to play a pivotal role in calcium-mediated intracellular processes, which are crucial for the proper functioning of cells.
Therapeutic significance:
Understanding the role of Copine-8 could open doors to potential therapeutic strategies. Its involvement in calcium-mediated processes suggests its potential impact on cellular functions and disease mechanisms.