Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8IUH8
UPID:
SPP2C_HUMAN
Alternative names:
Intramembrane protease 5
Alternative UPACC:
Q8IUH8; Q8TC67; Q8WVZ6
Background:
Signal peptide peptidase-like 2C, also known as Intramembrane protease 5, plays a crucial role in spermatogenesis. It functions as a sperm-specific intramembrane-cleaving aspartic protease (I-CLiP), targeting tail-anchored and SNARE proteins. This protease modulates intracellular Ca(2+) homeostasis by controlling PLN abundance and impacts vesicular trafficking essential for acrosome formation and compartment reorganization in spermatids.
Therapeutic significance:
Understanding the role of Signal peptide peptidase-like 2C could open doors to potential therapeutic strategies.