Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8IV77
UPID:
CNGA4_HUMAN
Alternative names:
Cyclic nucleotide-gated channel alpha-4
Alternative UPACC:
Q8IV77
Background:
Cyclic nucleotide-gated cation channel alpha-4 (CNGA4) serves as a modulatory subunit in cation-selective cyclic nucleotide-gated channels, pivotal in olfactory sensory neurons (OSNs). It plays a crucial role in odorant signal transduction and adaptation by accelerating calcium-mediated negative feedback, enhancing odor detection range.
Therapeutic significance:
Understanding the role of Cyclic nucleotide-gated cation channel alpha-4 could open doors to potential therapeutic strategies.