Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8IVB4
UPID:
SL9A9_HUMAN
Alternative names:
Na(+)/H(+) exchanger 9; Solute carrier family 9 member 9
Alternative UPACC:
Q8IVB4; A6NMQ9; Q3LIC2; Q5JPI6; Q5WA58; Q8NAB9
Background:
Sodium/hydrogen exchanger 9 (SLC9A9) functions as an endosomal Na(+), K(+)/H(+) antiporter, crucial for maintaining cellular ion homeostasis. It plays a pivotal role in regulating organellar pH, endosome maturation, and endocytic trafficking of plasma membrane receptors and neurotransporters. Additionally, SLC9A9 is involved in synaptic transmission and phagosome maturation, highlighting its multifaceted role in cellular physiology.
Therapeutic significance:
SLC9A9's association with Autism 16, a complex developmental disorder, underscores its potential as a therapeutic target. Understanding the role of Sodium/hydrogen exchanger 9 could open doors to potential therapeutic strategies, particularly in addressing neurological and developmental abnormalities.