Focused On-demand Library for Glucose-induced degradation protein 4 homolog

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.

We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.

The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.

We employ our advanced, specialised process to create targeted libraries.

Fig. 1. The sreening workflow of Receptor.AI

Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.

Our library stands out due to several important features:

The Receptor.AI platform compiles comprehensive data on the target protein, encompassing previous experiments, literature, known ligands, structural details, and more, leading to a higher chance of selecting the most relevant compounds.
Advanced molecular simulations on the platform help pinpoint potential binding sites, making the compounds in our focused library ideal for finding allosteric inhibitors and targeting cryptic pockets.
Receptor.AI boasts over 50 tailor-made AI models, rigorously tested and proven in various drug discovery projects and research initiatives. They are crafted for efficacy, dependability, and precision, all of which are key in creating our focused libraries.
Beyond creating focused libraries, Receptor.AI offers comprehensive services and complete solutions throughout the preclinical drug discovery phase. Our success-based pricing model minimises risk and maximises the mutual benefits of the project's success.

partner

Reaxense

upacc

Q8IVV7

UPID:

GID4_HUMAN

Alternative names:

Vacuolar import and degradation protein 24 homolog

Alternative UPACC:

Q8IVV7; Q8TEB5; Q9BW50

Background:

Glucose-induced degradation protein 4 homolog, also known as Vacuolar import and degradation protein 24 homolog, plays a crucial role in cellular homeostasis. It functions as a substrate-recognition subunit of the CTLH E3 ubiquitin-protein ligase complex, facilitating the ubiquitination and proteasomal degradation of HBP1. This protein exhibits specificity for peptides with a Pro/N-degron, showing a preference for sequences starting with an unmodified N-terminal Pro.

Therapeutic significance:

Understanding the role of Glucose-induced degradation protein 4 homolog could open doors to potential therapeutic strategies. Its involvement in protein degradation pathways highlights its potential as a target for modulating cellular processes implicated in various diseases.