Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8IWT0
UPID:
ARCH_HUMAN
Alternative names:
Protein ZBTB8OS; Zinc finger and BTB domain-containing opposite strand protein 8
Alternative UPACC:
Q8IWT0; Q5TGK5; Q6PDA1; Q8IWS9; Q8NEV6; Q8NEV7
Background:
Protein archease, also known as Protein ZBTB8OS and Zinc finger and BTB domain-containing opposite strand protein 8, plays a crucial role in the tRNA-splicing ligase complex. It is essential for the enzymatic turnover of catalytic subunit RTCB, working alongside DDX1 to facilitate RTCB's guanylylation, a pivotal step in tRNA ligation.
Therapeutic significance:
Understanding the role of Protein archease could open doors to potential therapeutic strategies. Its involvement in the fundamental process of tRNA ligation highlights its importance in cellular biology and presents an opportunity for targeted drug discovery.