Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8IX18
UPID:
DHX40_HUMAN
Alternative names:
DEAH box protein 40; Protein PAD
Alternative UPACC:
Q8IX18; B3KTJ5; C9JR60; Q5JPH4; Q8TC86; Q8WY53; Q9BXM1; Q9H6M9
Background:
The Probable ATP-dependent RNA helicase DHX40, also known as DEAH box protein 40 and Protein PAD, plays a crucial role in RNA metabolism. This protein is involved in the unwinding and remodeling of RNA structures, a fundamental process for RNA splicing, ribosome biogenesis, and other RNA-related functions.
Therapeutic significance:
Understanding the role of Probable ATP-dependent RNA helicase DHX40 could open doors to potential therapeutic strategies. Its pivotal function in RNA processing suggests its involvement in critical cellular processes, making it a significant target for drug discovery efforts.