Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8IXV7
UPID:
KLD8B_HUMAN
Alternative names:
-
Alternative UPACC:
Q8IXV7
Background:
Kelch domain-containing protein 8B plays a pivotal role in cell division, ensuring the accurate separation of nuclei during cytokinesis. It safeguards chromosomal stability, preventing mitotic errors and aneuploidy, thus maintaining genomic integrity. Its involvement in midbody function is crucial for the successful completion of cell division.
Therapeutic significance:
Given its critical role in cell division and chromosomal stability, Kelch domain-containing protein 8B is linked to classic Hodgkin lymphoma. Variants affecting its expression are associated with the disease, highlighting its potential as a target for therapeutic intervention in lymphoma treatment.