Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The procedure entails thorough molecular simulations of the catalytic and allosteric binding pockets, accompanied by ensemble virtual screening that factors in their conformational flexibility. When developing modulators, the structural modifications brought about by reaction intermediates are factored in to optimize activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8IYB8
UPID:
SUV3_HUMAN
Alternative names:
Suppressor of var1 3-like protein 1
Alternative UPACC:
Q8IYB8; A8K301; O43630
Background:
ATP-dependent RNA helicase SUPV3L1, mitochondrial, also known as Suppressor of var1 3-like protein 1, is a pivotal enzyme in mitochondrial RNA metabolism. It forms part of the mitochondrial degradosome complex, crucial for degrading double-stranded RNA in an ATP-dependent manner. This protein unwinds both DNA and RNA duplexes, playing a key role in mitochondrial RNA surveillance, stability of mRNAs, and chromatin maintenance. Its ability to prevent apoptosis underscores its importance in cellular survival.
Therapeutic significance:
Understanding the role of ATP-dependent RNA helicase SUPV3L1, mitochondrial could open doors to potential therapeutic strategies.