Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8IYF3
UPID:
TEX11_HUMAN
Alternative names:
Protein ZIP4 homolog
Alternative UPACC:
Q8IYF3; A8K8V6; Q5JQQ8; Q96LZ4; Q96M47; Q9BXU6
Background:
Testis-expressed protein 11, also known as Protein ZIP4 homolog, plays a pivotal role in male fertility. It acts as a regulator of crossing-over during meiosis, essential for the initiation and maintenance of chromosome synapsis and the formation of crossovers. This protein's function is crucial for the accurate segregation of chromosomes during the production of sperm cells.
Therapeutic significance:
The protein is directly linked to Spermatogenic failure, X-linked, 2, a disorder characterized by spermatogenesis defects leading to infertility. Understanding the role of Testis-expressed protein 11 could open doors to potential therapeutic strategies for treating male infertility issues.