Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8IYH5
UPID:
ZZZ3_HUMAN
Alternative names:
-
Alternative UPACC:
Q8IYH5; B7WPC6; Q6N004; Q6N070; Q8IYP0; Q8IYR1; Q8TEK4; Q9Y4U0
Background:
ZZ-type zinc finger-containing protein 3 plays a pivotal role in gene activation by maintaining histone acetylation through its function as a Histone H3 reader. As a crucial component of the ATAC complex, it exhibits histone acetyltransferase activity on histones H3 and H4, essential for regulating gene expression.
Therapeutic significance:
Understanding the role of ZZ-type zinc finger-containing protein 3 could open doors to potential therapeutic strategies.