Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8IZ73
UPID:
RUSD2_HUMAN
Alternative names:
RNA pseudouridylate synthase domain-containing protein 2
Alternative UPACC:
Q8IZ73; B4DDD1; Q7L989; Q92939; Q96IA7; Q96N50
Background:
Pseudouridylate synthase RPUSD2, also known as RNA pseudouridylate synthase domain-containing protein 2, plays a crucial role in the pseudouridylation of mRNAs. This enzymatic process is essential for the modification of RNA, influencing its stability, translation, and function.
Therapeutic significance:
Understanding the role of Pseudouridylate synthase RPUSD2 could open doors to potential therapeutic strategies. Its involvement in RNA modification processes positions it as a key player in cellular function and disease mechanisms.