Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
Q8IZS8
UPID:
CA2D3_HUMAN
Alternative names:
Voltage-gated calcium channel subunit alpha-2/delta-3
Alternative UPACC:
Q8IZS8; B2RPL6; Q9NY16; Q9NY18
Background:
The Voltage-dependent calcium channel subunit alpha-2/delta-3 plays a pivotal role in regulating calcium current density and the activation/inactivation kinetics of calcium channels. It serves as a regulatory subunit for various types of calcium channels, including P/Q-type, N-type, and L-type, but not T-type. This specificity underscores its critical function in calcium signaling pathways.
Therapeutic significance:
Understanding the role of Voltage-gated calcium channel subunit alpha-2/delta-3 could open doors to potential therapeutic strategies. Its regulatory function in calcium channel activity makes it a compelling target for the development of drugs aimed at modulating calcium signaling in disease conditions.