Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8N1F7
UPID:
NUP93_HUMAN
Alternative names:
93 kDa nucleoporin; Nucleoporin Nup93
Alternative UPACC:
Q8N1F7; B3KPQ8; Q14705
Background:
Nuclear pore complex protein Nup93, also known as a 93 kDa nucleoporin, is integral to the nuclear pore complex (NPC) assembly and maintenance. It is pivotal in anchoring nucleoporins within the NPC, excluding NUP153 and TPR. Furthermore, Nup93 plays a crucial role in renal development by regulating podocyte migration and proliferation via SMAD4 signaling pathways.
Therapeutic significance:
Nup93's involvement in Nephrotic syndrome 12, a severe renal disorder leading to end-stage renal failure, underscores its therapeutic potential. Understanding the role of Nuclear pore complex protein Nup93 could open doors to potential therapeutic strategies for this autosomal recessive disease.