Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8N3C0
UPID:
ASCC3_HUMAN
Alternative names:
ASC-1 complex subunit p200; Helicase, ATP binding 1; Trip4 complex subunit p200
Alternative UPACC:
Q8N3C0; E7EW23; O43738; Q4G1A0; Q5VTN2; Q9H1I9; Q9H5A2; Q9NTR0
Background:
Activating signal cointegrator 1 complex subunit 3 (ASC-1 complex subunit p200) plays a pivotal role in DNA repair and ribosome quality control. It functions as an ATPase, facilitating DNA unwinding for repair processes and driving the splitting of stalled ribosomes. This protein is part of the ASC-1 complex, enhancing transactivation of key transcription factors.
Therapeutic significance:
Understanding the role of Activating signal cointegrator 1 complex subunit 3 could open doors to potential therapeutic strategies.