Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8N3Y1
UPID:
FBXW8_HUMAN
Alternative names:
F-box and WD-40 domain-containing protein 8; F-box only protein 29
Alternative UPACC:
Q8N3Y1; Q9UK95
Background:
F-box/WD repeat-containing protein 8, also known as F-box and WD-40 domain-containing protein 8 or F-box only protein 29, plays a crucial role in cellular processes. It acts as a substrate-recognition component of the Cul7-RING ubiquitin-protein ligase complex, facilitating the ubiquitination and proteasomal degradation of target proteins. This protein is pivotal in regulating Golgi morphogenesis, dendrite patterning in the brain, and cell proliferation and differentiation through the degradation of specific substrates like GORASP1, IRS1, and MAP4K1/HPK1.
Therapeutic significance:
Understanding the role of F-box/WD repeat-containing protein 8 could open doors to potential therapeutic strategies.