Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8N4E7
UPID:
FTMT_HUMAN
Alternative names:
-
Alternative UPACC:
Q8N4E7
Background:
Ferritin, mitochondrial, encoded by the gene with accession number Q8N4E7, plays a crucial role in iron metabolism. It catalyzes the oxidation of ferrous iron (II) to ferric iron (III), facilitating iron storage in a soluble, non-toxic form. This process is vital for maintaining iron homeostasis, ensuring that iron is readily available for biological processes while preventing iron-induced toxicity.
Therapeutic significance:
Understanding the role of Ferritin, mitochondrial could open doors to potential therapeutic strategies. Its pivotal function in iron homeostasis makes it a key target for addressing disorders related to iron metabolism and storage.