Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
Q8N4H5
UPID:
TOM5_HUMAN
Alternative names:
-
Alternative UPACC:
Q8N4H5; B2DG07; F6S928; Q5JRT7
Background:
The Mitochondrial import receptor subunit TOM5 homolog plays a crucial role in the mitochondrial import machinery, facilitating the translocation of proteins from the cytosol into the mitochondrion. This process is vital for mitochondrial function and energy production in cells.
Therapeutic significance:
Understanding the role of Mitochondrial import receptor subunit TOM5 homolog could open doors to potential therapeutic strategies. Its involvement in mitochondrial function suggests its potential impact on diseases related to mitochondrial dysfunction.