Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8N4N8
UPID:
KIF2B_HUMAN
Alternative names:
-
Alternative UPACC:
Q8N4N8; Q96MA2; Q9BXG6
Background:
Kinesin-like protein KIF2B is a pivotal microtubule-dependent motor, essential for spindle assembly and chromosome movement during cell division. It exhibits microtubule depolymerization activity, crucial for chromosome congression, ensuring accurate chromosome alignment and segregation.
Therapeutic significance:
Understanding the role of Kinesin-like protein KIF2B could open doors to potential therapeutic strategies. Its critical function in cell division highlights its potential as a target in cancer therapy, where regulation of cell proliferation is a key challenge.