Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8N573
UPID:
OXR1_HUMAN
Alternative names:
-
Alternative UPACC:
Q8N573; A6NK11; A8KA34; B3KXL1; B7Z402; B7Z8N5; D3HIS6; Q3LIB5; Q6ZVK9; Q8N8V0; Q9H266; Q9NWC7
Background:
Oxidation resistance protein 1 plays a crucial role in cellular defense mechanisms, primarily through its involvement in protecting cells from oxidative damage. This protein's function is pivotal in maintaining cellular integrity and function by mitigating the detrimental effects of oxidative stress, which can lead to cellular damage and disease.
Therapeutic significance:
The association of Oxidation resistance protein 1 with Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay highlights its potential therapeutic significance. Understanding the role of Oxidation resistance protein 1 could open doors to potential therapeutic strategies aimed at treating or managing this neurodevelopmental disorder.