Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8N6I4
UPID:
LYSET_HUMAN
Alternative names:
GNPTAB cleavage and activity factor; Transmembrane protein 251
Alternative UPACC:
Q8N6I4; J3KQ65; Q9Y4S5
Background:
The Lysosomal enzyme trafficking factor, also known as GNPTAB cleavage and activity factor or Transmembrane protein 251, plays a pivotal role in mannose-6-phosphate-dependent trafficking of lysosomal enzymes. It acts as a bridge for the proteolytic activation of GNPTAB, crucial for Golgi-to-lysosome transport of lysosomal enzymes, and is indispensable for the maturation and delivery of lysosomal hydrolases.
Therapeutic significance:
Linked to Dysostosis multiplex, Ain-Naz type, a severe skeletal disease, understanding the role of Lysosomal enzyme trafficking factor could open doors to potential therapeutic strategies.