Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8N6T0
UPID:
TO6BL_HUMAN
Alternative names:
TOP6B like initiator of meiotic double strand breaks; Type 2 DNA topoisomerase VI subunit B-like
Alternative UPACC:
Q8N6T0; Q9H677
Background:
Type 2 DNA topoisomerase 6 subunit B-like, also known as TOP6B like initiator of meiotic double strand breaks, plays a crucial role in meiotic recombination. It is a component of a topoisomerase 6 complex that, alongside SPO11, mediates DNA cleavage forming double-strand breaks essential for initiating meiotic recombination. This process facilitates the relaxation and decatenation of DNA through cleavage and ligation cycles.
Therapeutic significance:
The protein's involvement in Hydatidiform mole, recurrent, 4, a disorder characterized by abnormal pregnancies, underscores its potential as a target for therapeutic intervention. Understanding the role of Type 2 DNA topoisomerase 6 subunit B-like could open doors to potential therapeutic strategies.