Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8N766
UPID:
EMC1_HUMAN
Alternative names:
-
Alternative UPACC:
Q8N766; A8K6F3; Q14700; Q5TG62; Q63HL0; Q63HL3; Q8NBH8
Background:
ER membrane protein complex subunit 1 plays a crucial role in the insertion of newly synthesized membrane proteins into the endoplasmic reticulum (ER) membrane. It is part of the endoplasmic reticulum membrane protein complex (EMC) and is essential for the cotranslational and post-translational insertion of membrane proteins, ensuring their proper orientation and functionality.
Therapeutic significance:
The protein is linked to Cerebellar atrophy, visual impairment, and psychomotor retardation, a neurodegenerative disorder. Understanding the role of ER membrane protein complex subunit 1 could open doors to potential therapeutic strategies for this condition.