Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8N7U6
UPID:
EFHB_HUMAN
Alternative names:
Cilia- and flagella-associated protein 21
Alternative UPACC:
Q8N7U6; A6ND25; A8MPR3; Q6ZWK9; Q8IV58; Q96LQ6
Background:
EF-hand domain-containing family member B, also known as Cilia- and flagella-associated protein 21, plays a crucial role in cellular processes. It acts as a cytosolic sensor for calcium, influencing the interaction between STIM1 and ORAI1, which is vital for the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation. Additionally, it is a key component of the dynein-decorated doublet microtubules in cilia axoneme, essential for motile cilia beating.
Therapeutic significance:
Understanding the role of EF-hand domain-containing family member B could open doors to potential therapeutic strategies.