Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
Q8N807
UPID:
PDILT_HUMAN
Alternative names:
-
Alternative UPACC:
Q8N807; Q8IVQ5
Background:
The Protein disulfide-isomerase-like protein of the testis, identified by the accession number Q8N807, plays a crucial role in spermatogenesis. As a probable redox-inactive chaperone, it is involved in the folding and assembly of other proteins within the testis, ensuring their proper function and stability.
Therapeutic significance:
Understanding the role of Protein disulfide-isomerase-like protein of the testis could open doors to potential therapeutic strategies. Its involvement in spermatogenesis highlights its importance in fertility and reproductive health, suggesting that targeting this protein could lead to novel treatments for male infertility.