Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8N8E2
UPID:
ZN513_HUMAN
Alternative names:
-
Alternative UPACC:
Q8N8E2; A8K3S5; B7WP71; Q3ZCU1; Q68CJ1; Q86UZ3; Q8NDL8; Q96ML3
Background:
Zinc finger protein 513 plays a pivotal role in retinal development and maintenance, acting as a transcriptional regulator. This protein's involvement in the intricate processes of the eye underscores its importance in visual function.
Therapeutic significance:
Linked to Retinitis pigmentosa 58, a condition characterized by night vision blindness and progressive loss of visual field, Zinc finger protein 513's role in this disease highlights its potential as a target for therapeutic intervention.