Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8NAV1
UPID:
PR38A_HUMAN
Alternative names:
-
Alternative UPACC:
Q8NAV1; Q96JW1; Q9BVZ8
Background:
Pre-mRNA-splicing factor 38A plays a crucial role in the splicing of pre-mRNA as part of the spliceosome complex. This process is essential for the correct expression of genes, ensuring that introns are removed and exons are joined together accurately.
Therapeutic significance:
Understanding the role of Pre-mRNA-splicing factor 38A could open doors to potential therapeutic strategies. Its pivotal function in gene expression regulation highlights its potential as a target for interventions in genetic disorders.