Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8NBH2
UPID:
KY_HUMAN
Alternative names:
-
Alternative UPACC:
Q8NBH2; B7Z1S4; Q6ZT15
Background:
Kyphoscoliosis peptidase, encoded by the gene with accession number Q8NBH2, plays a crucial role in muscle development and neuromuscular junction stability. It is believed to function as a cytoskeleton-associated protease, essential for normal muscle growth by potentially cleaving muscle-specific proteins such as FLNC.
Therapeutic significance:
The protein is implicated in Myopathy, myofibrillar, 7, a neuromuscular disorder marked by muscle weakness and atrophy. Understanding the role of Kyphoscoliosis peptidase could open doors to potential therapeutic strategies for treating this condition.