Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8NBR6
UPID:
MINY2_HUMAN
Alternative names:
Deubiquitinating enzyme MINDY-2; Protein FAM63B
Alternative UPACC:
Q8NBR6; B2RTT8; Q9ULQ6
Background:
Ubiquitin carboxyl-terminal hydrolase MINDY-2, also known as Deubiquitinating enzyme MINDY-2 and Protein FAM63B, is a hydrolase that specializes in removing 'Lys-48'-linked conjugated ubiquitin from proteins. It exhibits binding affinity to polyubiquitin chains of various linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48', and 'Lys-63'. This enzyme plays a crucial regulatory role in protein turnover.
Therapeutic significance:
Understanding the role of Ubiquitin carboxyl-terminal hydrolase MINDY-2 could open doors to potential therapeutic strategies.