Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
Q8NE71
UPID:
ABCF1_HUMAN
Alternative names:
ATP-binding cassette 50; TNF-alpha-stimulated ABC protein
Alternative UPACC:
Q8NE71; A2BF75; O14897; Q69YP6
Background:
ATP-binding cassette sub-family F member 1, also known as ATP-binding cassette 50 and TNF-alpha-stimulated ABC protein, plays a crucial role in mRNA translation initiation. Specifically, Isoform 2 of this protein is essential for efficient Cap- and IRES-mediated mRNA translation initiation, although it does not participate in ribosome biogenesis.
Therapeutic significance:
Understanding the role of ATP-binding cassette sub-family F member 1 could open doors to potential therapeutic strategies. Its involvement in mRNA translation initiation suggests its potential impact on protein synthesis, offering a promising avenue for research into diseases where protein synthesis regulation is disrupted.