Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
Q8NEM7
UPID:
SP20H_HUMAN
Alternative names:
p38-interacting protein
Alternative UPACC:
Q8NEM7; E7ER46; Q71RF3; Q9Y6A6
Background:
Transcription factor SPT20 homolog, also known as p38-interacting protein, plays a pivotal role in cellular processes. It is essential for MAP kinase p38 activation during gastrulation, influencing cell differentiation and development. This protein also regulates E-cadherin levels, impacting cell adhesion and migration, and is involved in autophagy through ATG9A trafficking under starvation conditions.
Therapeutic significance:
Understanding the role of Transcription factor SPT20 homolog could open doors to potential therapeutic strategies. Its involvement in key cellular processes such as cell differentiation, adhesion, and autophagy highlights its potential as a target in regenerative medicine and cancer therapy.